GeneType™ Risk Test Kit

• Understand your assessed risk of developing certain health conditions

• Personalised risk assessment based on genetic and clinical risk factors

• Simple saliva collection

• Personalised risk information to support discussions with your healthcare provider

• Genetic counselling may be available following testing

Genetic discrimination laws may not provide protection in all circumstances or in the future. This may be relevant when applying for certain types of insurance, including life or disability insurance. Consider obtaining independent advice about the implications of genetic testing before proceeding.

About the GeneType™ Risk Test

The GeneType™ Risk Test combines genetic and clinical risk factors to provide an individualised assessment of risk for certain health conditions.

The results are designed to provide additional information that may support discussions with your healthcare provider about appropriate screening, risk-management and lifestyle considerations.

GeneType™ reports combine relevant genetic, clinical and family-history information to provide an individualised risk assessment. Results should be considered alongside your personal medical history and discussed with your healthcare provider.

Understanding your assessed risk may help you and your healthcare provider have more informed conversations about appropriate screening and risk-management options.

Breast Cancer – lifetime and 5-year risk assessment

The GeneType™ Breast Cancer Risk Test combines common genetic risk factors with clinical and family-history information to provide an individualised assessment of breast cancer risk.

This test assesses common genetic factors associated with breast cancer risk. It does not test for hereditary pathogenic variants such as BRCA1 or BRCA2.

The test may be appropriate for certain women who do not have a known hereditary breast cancer pathogenic variant, subject to the applicable eligibility criteria.

The assessment incorporates factors including:

• Common genetic markers associated with breast cancer risk

• Age

• Family history of breast cancer

• Body mass index

• Breast density, where available

• Menopausal status

The results provide an individualised risk assessment that can be discussed with your healthcare provider in the context of your personal and family history.

Depending on the assessed risk and individual circumstances, your healthcare provider may discuss options such as:

• Appropriate breast screening

• Mammography

• MRI or ultrasound where clinically appropriate

• Referral to an appropriate specialist

• Risk-management strategies

• Lifestyle factors including physical activity, diet, smoking and alcohol consumption

• Other risk-management options where clinically appropriate

Important: GeneType™ does not replace recommended breast screening or hereditary genetic testing where this is clinically indicated.

Colorectal Cancer – lifetime and 10-year risk assessment

The GeneType™ Colorectal Cancer Risk Test combines common genetic risk factors with clinical and family-history information to provide an individualised assessment of colorectal cancer risk.

Colorectal cancer risk can be influenced by a range of factors, including age, genetics, family history, lifestyle and other clinical factors.

GeneType™ provides additional risk information that can be considered alongside your existing medical and family history.

GeneType™ does not replace routine colorectal cancer screening. Screening recommendations should be discussed with your healthcare provider.

The applicable eligibility criteria include age and relevant medical history. The test is not intended for people with a personal history of colorectal cancer or certain known hereditary cancer syndromes.

Depending on the assessed risk and individual circumstances, your healthcare provider may discuss:

• Appropriate colorectal cancer screening

• Colonoscopy or other screening options where clinically appropriate

• Referral to an appropriate specialist

• Lifestyle and risk-management considerations

Ovarian Cancer – lifetime and 10-year risk assessment

The GeneType™ Ovarian Cancer Risk Test provides an individualised assessment of ovarian cancer risk based on relevant genetic and clinical factors.

The assessment may incorporate factors including:

• Common genetic risk factors

• Age

• Ethnicity

• Hormonal medication history

• Menopausal status

• Parity

• Previous oophorectomy

Eligibility criteria apply, including relevant age and hereditary cancer history.

Results should be discussed with your healthcare provider in the context of your personal and family history.

Prostate Cancer – lifetime and 5-year risk assessment

The GeneType™ Prostate Cancer Risk Test provides an individualised assessment of prostate cancer risk based on relevant genetic and clinical risk factors.

The assessment may provide additional information to support discussions with your healthcare provider about appropriate screening and risk-management options.

Eligibility criteria apply, including age and relevant hereditary genetic history.

Pancreatic Cancer – lifetime and 10-year risk assessment

The GeneType™ Pancreatic Cancer Risk Test provides an individualised assessment of pancreatic cancer risk based on relevant genetic and clinical risk factors.

Cancer risk is influenced by multiple factors. GeneType™ incorporates selected risk factors included within the applicable risk assessment model.

Eligibility criteria apply, including age and relevant medical and hereditary history.

Results should be discussed with your healthcare provider and considered alongside your broader medical and family history.

Melanoma – lifetime and 10-year risk assessment

The GeneType™ Melanoma Risk Test provides an individualised assessment of melanoma risk based on relevant genetic and clinical risk factors.

The assessment may incorporate factors such as:

• Genetic risk factors

• Skin and hair characteristics

• History of tanning bed use

• Number of naevi

Eligibility criteria apply.

Results should be discussed with your healthcare provider in the context of your personal history and other risk factors.

Coronary Artery Disease – 10-year risk assessment

The GeneType™ Coronary Artery Disease Risk Test combines genetic, clinical and family-history factors to provide an individualised assessment of coronary artery disease risk.

The assessment may be considered alongside established clinical risk factors and should be interpreted in the context of your overall health and medical history.

Depending on the assessed risk, your healthcare provider may discuss appropriate screening and risk-management options.

Type 2 Diabetes – 8-year risk assessment

The GeneType™ Type 2 Diabetes Risk Test combines genetic, clinical and family-history factors to provide an individualised assessment of type 2 diabetes risk.

The results can provide additional information to support discussions with your healthcare provider about risk-management and lifestyle considerations.

Eligibility criteria apply and may include age and relevant clinical measurements.

Who can order a GeneType™ Risk Test?

GeneType™ testing should be discussed with your healthcare provider before ordering.

Eligibility varies depending on the specific GeneType™ risk assessment, your age, sex and personal and family medical history.

Some assessments may not be appropriate for people who have previously been diagnosed with the relevant condition or who have a known pathogenic genetic variant or hereditary syndrome.

Your healthcare provider can determine whether a particular GeneType™ assessment is appropriate for you.

Genetic counselling

Genetic counselling may be available to help you understand your GeneType™ results and what they may mean in the context of your personal and family history.

Understanding your results

Following a GeneType™ assessment, your healthcare provider can discuss your personalised report with you and explain the results in the context of your overall health.

The results may support shared discussions about screening, monitoring and risk-management options that are appropriate for your individual circumstances.

GeneType™ is a risk assessment and does not diagnose cancer or other disease.

Important information

GeneType™ risk assessments provide an estimate of risk based on the information and risk factors included in the relevant assessment model. A result does not mean that you will or will not develop a particular condition.

Results should be considered alongside your personal medical history, family history and other relevant clinical information.

GeneType™ does not replace recommended screening, diagnostic testing or medical care.

Please discuss your results with your healthcare provider.

Eligibility

Eligibility requirements vary according to the individual GeneType™ assessment.

Some tests require:

• A specified age range

• No previous diagnosis of the relevant condition

• No known pathogenic variant or hereditary syndrome relevant to the assessment

• Recent clinical information or pathology results, where applicable

Your healthcare provider will assess your eligibility before testing.

Insurance and genetic information

Laws relating to the use of genetic information by insurers and other organisations may change and may not provide protection in all circumstances. Consider obtaining independent advice before undertaking genetic testing if you have concerns about future insurance applications.

Important: Please ensure you meet the eligibility requirements for the specific GeneType™ assessment before ordering.

GeneType™ Risk Test is a risk assessment tool. It does not diagnose disease and should not be used as a substitute for medical advice, diagnosis or recommended screening.