{"product_id":"vibrant-america-neural-zoomer-plus-test","title":"Vibrant America Neural Zoomer Plus Test","description":"\u003cp\u003e\u003cstrong\u003eExpansive Neurological Auto-Antibody Test\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSingle Patient Blood Test\u003c\/p\u003e\n\u003cp\u003eThe Neural Zoomer\u003cspan\u003e \u003c\/span\u003ePlus is an array of 48 of the most common autoantibodies associated with neurological autoimmunity and cognitive decline, which offers very specific antibody-to-antigen recognition. The Vibrant Neural Zoomer\u003cspan\u003e \u003c\/span\u003ePlus is designed to assess an individual’s reactivity to 48 neurological antigens, which may have connections to a variety of neurologically related diseases. \u003ca rel=\"noopener noreferrer\" href=\"https:\/\/evergreendoctors.squarespace.com\/s\/neural-zoomer-plus-sample-report.pdf\" target=\"_blank\"\u003eNeural Zoomer Plus Sample Report\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eThe test also has \u003cstrong\u003eoptional additional genetic testing for the ApoE genotype\u003c\/strong\u003e, which has been shown to influence risk for certain neurological conditions.\u003c\/p\u003e\n\u003cp\u003eWith a panel of 48 of the most well-studied neurological autoantibodies, the Neural Zoomer\u003cspan\u003e \u003c\/span\u003ePlus is able to pinpoint the mechanisms behind disease progression to help provide a roadmap to solutions and improved health outcomes in this challenging arena of disease. The Vibrant Neural Zoomer\u003cspan\u003e \u003c\/span\u003ePlus aims to reduce the prevalence of neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalised primary prevention.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eMarkers Measured:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cu\u003eDemyelination Antigens\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-Tubulin:\u003c\/strong\u003e Associated with alcoholic liver disease, demyelinating disease, Grave’s disease, Hashimoto’s thyroiditis, infectious agent exposure PANDAS\/ANDAS\/OCD, rheumatoid arthritis, and recent onset type 1 diabetes.\u003cbr\u003e\u003cstrong\u003eAnti-Myelin basic protein\u003c\/strong\u003e: Related to the risk for multiple sclerosis, autism, PANDAS\/ANDAS\/OCD, and systemic lupus erythematosus (SLE).\u003cbr\u003e\u003cstrong\u003eAnti-Myelin oligodendrocyte glycoprotein (MOG):\u003c\/strong\u003e Found in various demyelinating diseases, including multiple sclerosis, neuromyelitis optica spectrum disorders (NMOSD), idiopathic optic neuritis (ON), acute disseminated encephalomyelitis (ADEM), multiphasic disseminated encephalomyelitis (MDEM), Devic’s disease, and tumefactive demyelinating disease.\u003cbr\u003e\u003cstrong\u003eAnti-Myelin proteolipid protein:\u003c\/strong\u003e A useful marker in patients with seronegative anti-myelin basic protein, the frequent marker in active multiple sclerosis and optic neuritis.\u003cbr\u003e\u003cstrong\u003eAnti-Neurofascin:\u003c\/strong\u003e Found mainly in combined central and peripheral demyelination (CCPD), a rare demyelinating condition affecting both CNS and peripheral nervous system (PNS) tissues, and also in chronic inflammatory demyelinating polyneuropathy (CIDP) and axonal injury in patients with multiple sclerosis (MS).\u003cbr\u003e\u003cstrong\u003eAnti-MAG:\u003c\/strong\u003e Anti-MAG peripheral neuropathy is a very rare disease caused by anti-MAG antibodies that destroy MAG protein leading to disruptions of normal myelin production and healthy peripheral nerve activity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cu\u003eBlood Brain Barrier Disruption\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-s100b:\u003c\/strong\u003e Blood brain barrier integrity breach and sub-concussive episodes lead to the production of this antibody. Extravasated s100B may trigger a pathologic autoimmune reaction linking systemic and CNS immune responses.\u003cbr\u003e\u003cstrong\u003eAnti-Glial fibrillary acidic protein:\u003c\/strong\u003e Anti-GFAP is produced when the protein enters the bloodstream after a rupture of the blood brain barrier, thus serves as a blood based diagnostic marker of brain injury.\u003cbr\u003e\u003cstrong\u003eAnti-Microglia:\u003c\/strong\u003e Indicate a destruction of the blood brain barrier and are found to play a role in tissue destruction of Alzheimer’s disease.\u003cbr\u003e\u003cstrong\u003eAnti-Glucose regulated protein 78:\u003c\/strong\u003e Glucose-regulated protein 78–targeted antibodies could instigate bloodbrain barrier breakdown and development of hallmark anti–aquaporin-4 autoantibody pathology.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cu\u003eOptical and Autonomic Nervous System Disorders\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-Neuron specific enolase:\u003c\/strong\u003e Antibodies against neuron specific enolase are found in patients with optical neuropathies.\u003cbr\u003e\u003cstrong\u003eAnti-Aquaporin 4\u003c\/strong\u003e: AQP4 IgG is involved in the development of neuromyelitis optica and revolutionized the understanding of the disease. Anti-Aquaporin4 antibodies have also been shown in patients with peripheral demyelination.\u003cbr\u003e\u003cstrong\u003eAnti-Recoverin\u003c\/strong\u003e: One of the key components of antibody disorders of the CNS. They have also been shown to be associated with retinopathy which is characterized by impaired vision and photosensitivity.\u003cbr\u003e\u003cstrong\u003eAnti-CV2\u003c\/strong\u003e: Seen in autoimmune paraneoplastic autonomic neuropathy and mixed axonal and demyelinating peripheral neuropathy\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cu\u003ePeripheral Neuropathy\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-GM1\u003c\/strong\u003e: Associated with multi-focal motor neuropathy and lower motor neuropathy, characterized by muscle weakness and atrophy\u003cbr\u003e\u003cstrong\u003eAnti-GM2:\u003c\/strong\u003e A potential peripheral nerve antigen for neuropathy-associated autoantibodies\u003cbr\u003e\u003cstrong\u003eAnti-Hu:\u003c\/strong\u003e The most frequent manifestation of sensory neuropathy with frequent autonomic involvement\u003cbr\u003e\u003cstrong\u003eAnti-Ri:\u003c\/strong\u003e Can be detected in patients with the paraneoplastic opsoclonus\/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, gynecological cancers, and small cell lung cancer.\u003cbr\u003e\u003cstrong\u003eAnti-Amphiphysin:\u003c\/strong\u003e Often found in the serum of patients with stiff-person syndrome\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cu\u003eNeuromuscular disorders\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-Acetylcholine receptors:\u003c\/strong\u003e Found in myasthenia gravis disease which destroys the receptor function, leading to a neuromuscular transmission defect, which then causes hypofunction, fatigue, and inflammation of skeletal muscles and produces serum antibodies against muscle antigens\u003cbr\u003e\u003cstrong\u003eAnti-Muscle specific kinase:\u003c\/strong\u003e An important marker in patients without anti-acetylcholine receptor antibodies in myasthenia gravis disease\u003cbr\u003e\u003cstrong\u003eAnti-Voltage gated calcium channels:\u003c\/strong\u003e Responsible for Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune disorder of the neuromuscular junction\u003cbr\u003e\u003cstrong\u003eAnti-Voltage gated potassium channels\u003c\/strong\u003e: Downregulate the potassium channels expressed on the peripheral nerve terminal leading to nerve hyperexcitability\u003cbr\u003e\u003cstrong\u003eAnti-Titin:\u003c\/strong\u003e Present in 70–90% of thymoma autoimmune myasthenia gravis (MG) patients, and in approximately 50% of late-onset acetylcholine-MG patients without thymoma\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cu\u003eBrain Autoimmunity\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-Purkinje cell:\u003c\/strong\u003e Autoimmunity to a class of GABAergic neurons located in the cerebellum, which can produce abnormalities and decline in gross motor functions\u003cbr\u003e\u003cstrong\u003eAnti-Yo:\u003c\/strong\u003e Suggest that a patient with neurologic symptoms has a paraneoplastic syndrome. In addition, their presence also often suggests the nature of the underlying tumor.\u003cbr\u003e\u003cstrong\u003eAnti-Amyloid beta (25-35):\u003c\/strong\u003e Levels of autoantibodies reacting with oligomers of the short, neurotoxic fragment Aβ (25-35) are significantly higher in AD patients than in healthy controls\u003cbr\u003e\u003cstrong\u003eAnti-Amyloid beta (1-42):\u003c\/strong\u003e A signature marker in Alzheimer’s disease\u003cbr\u003e\u003cstrong\u003eAnti-RAGE peptide:\u003c\/strong\u003e Found in Alzheimer’s disease patients, and particularly higher in AD patients with diabetes\u003cbr\u003e\u003cstrong\u003eAnti-Tau:\u003c\/strong\u003e Found in the neurofibrillary tangles in brains of individuals who have Alzheimer’s disease\u003cbr\u003e\u003cstrong\u003eAnti-Glutamate:\u003c\/strong\u003e Found in epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren’s syndrome, schizophrenia, mania or stroke\u003cbr\u003e\u003cstrong\u003eAnti-Dopamine:\u003c\/strong\u003e Associated with movement disorders characterized by parkinsonism, dystonia, and Sydenham chorea\u003cbr\u003e\u003cstrong\u003eAnti-Hydroxytryptamine:\u003c\/strong\u003e Found mainly in autoimmune encephalitis\u003cbr\u003e\u003cstrong\u003eAnti-Alpha-synuclein:\u003c\/strong\u003e Mainly elevated in Parkinson’s disease and Alzheimer’s disease\u003cbr\u003e\u003cstrong\u003eAnti-α1 and β2 adrenergic receptors:\u003c\/strong\u003e Found mainly in patients with different dementia forms such as unclassified, Lewy body, vascular, and Alzheimer’s dementia\u003cbr\u003e\u003cstrong\u003eAnti-Endothelin A receptor:\u003c\/strong\u003e Found in vascular dementia\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cu\u003eBrain Inflammation\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-NMDA receptor:\u003c\/strong\u003e Found in anti-NMDA receptor encephalitis\u003cbr\u003e\u003cstrong\u003eAnti-AMPA receptor\u003c\/strong\u003e: May play a role in Alzheimer’s disease, characterized by decreased AMPA activation and synapse loss\u003cbr\u003e\u003cstrong\u003eAnti-Dopamine receptors:\u003c\/strong\u003e Associated with Parkinson’s disease and other disorders of low dopamine status\u003cbr\u003e\u003cstrong\u003eAnti-GABA receptors:\u003c\/strong\u003e Associated with temporal lobe epilepsy (TLE), Parkinson’s disease (PD) and Huntington’s disease (HD) and other neurodegenerative disorders that involve disruptions in gamma-amino butyric acid (GABA) signalling\u003cbr\u003e\u003cstrong\u003eAnti-Dipeptidyl aminopeptidase-like protein 6:\u003c\/strong\u003e Associated with encephalitis\u003cbr\u003e\u003cstrong\u003eAnti-Glycine receptor:\u003c\/strong\u003e Helpful in the diagnosis of patients with symptoms and signs that include ocular motor and other brainstem dysfunction, hyperekplexia, stiffness, rigidity, myoclonus and spasms\u003cbr\u003e\u003cstrong\u003eAnti-Neurexin 3:\u003c\/strong\u003e Associated with a severe but potentially treatable encephalitis in which the antibodies cause a decrease of neurexin-3α and alter synapse development\u003cbr\u003e\u003cstrong\u003eAnti-Contactin-associated protein-like 2\u003c\/strong\u003e: Diseases associated with CNTNAP2 include Pitt-Hopkins-Like Syndrome 1 and Autism 15\u003cbr\u003e\u003cstrong\u003eAnti-Leucine-rich glioma-inactivated protein 1:\u003c\/strong\u003e LGI1 antibody–associated encephalitis has increasingly been recognized as a primary autoimmune disorder\u003cbr\u003e\u003cstrong\u003eAnti-Ma:\u003c\/strong\u003e Present in men with testicular tumors and isolated or combined limbic encephalitis (LE), diencephalic encephalitis (DE), or brainstem encephalitis (BE)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cu\u003eInfections\u003c\/u\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-HSV-1:\u003c\/strong\u003e HSV-1 has been reported to have a pathogenesis role in Herpes simplex encephalitis (HSE) and seropositivity to HSV-1 antibodies has been correlated with increased risk of Alzheimer’s disease\u003cbr\u003e\u003cstrong\u003eAnti-HSV-2:\u003c\/strong\u003e Herpes simplex encephalitis (HSE) is a disorder commonly associated with HSV-2. HSE due to HSV-2 may occur without meningitis features. Antibodies against HSV-2 have shown positive correlation in patients with symptoms of HSE.\u003cbr\u003e\u003cstrong\u003eAnti-EBV:\u003c\/strong\u003e Antibodies against the EBV nuclear antigen complex (EBNAc) and EBNA-1 have been correlated with increased risk of multiple sclerosis (MS).\u003cbr\u003e\u003cstrong\u003eAnti-CMV:\u003c\/strong\u003e Cytomegalovirus (CMV) infections have been reported frequently to be associated with Guillain–Barre syndrome (GBS). There is a potential for molecular mimicry between GM2 and antigens induced by CMV infection.\u003cbr\u003e\u003cstrong\u003eAnti-HHV-6:\u003c\/strong\u003e Human herpesvirus-6 (HHV-6) is frequently associated with neurologic diseases, including multiple sclerosis (MS), epilepsy, encephalitis, and febrile illness.\u003cbr\u003e\u003cstrong\u003eAnti-HHV-7:\u003c\/strong\u003e HHV-7 has been less frequently associated with CNS disease than HHV-6, but found to be associated with encephalitis, meningitis, and demyelinating conditions. Similar to HHV 6A, increased levels of HHV-7 were found in multiple brain regions in Alzheimer’s disease (AD) patients.\u003cbr\u003e\u003cstrong\u003eAnti-Streptococcal A:\u003c\/strong\u003e Anti-streptococcal A antibodies are shown to cross react with different brain proteins that could lead to neuropsychiatric symptoms including PANDAS characterized by paediatric obsessive-compulsive disorder (OCD) and tic disorder, and Sydenham Chorea.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe test pricing includes the mailing of the blood collection kit from the USA, return shipping to the USA, and the lab test analysis in the USA. \u003c\/p\u003e\n\u003cp\u003eThe kit usually takes 14 business days to arrive from the USA. If you have not received your kit within 14 days, please email us\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eat\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"mailto:evergreenoptilabs@gmail.com\"\u003eevergreenoptilabs@gmail.com\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYou may like to arrange a blood collection at our office for a $50 fee, so it just 1 needle, otherwise you can use the home finger prick test kit yourself.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe lab does intermittently change from a home test kit to blood tubes, due to supply issues. If you receive blood tubes you'll need a pathology form from us, and you will need to go to your local pathology centre. They will charge a small fee, you take the blood tubes back, and send them back to the USA using the kit and pre paid shipping info from Vibrant.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"text-align: center;\"\u003e \u003c\/p\u003e\n\u003cp\u003e *Please note - the lab has extended the turn around time for results now to 30 days from receipt at the USA lab *\u003c\/p\u003e\n\u003cp\u003e \u003cstrong\u003e**You must send us your Date of Birth for the lab to send your test it, please ensure you\u003cspan\u003e \u003c\/span\u003edo\u003cspan\u003e \u003c\/span\u003ethis after you order **\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eBy ordering you acknowledge the test is intended for research, educational, and informational use only. Discuss results with your healthcare provider. All test samples must be received within 3 months of ordering or additional fees may apply.\u003c\/span\u003e\u003c\/p\u003e","brand":"Vibrant","offers":[{"title":"Neural Zoomer Plus (NO Add-On)","offer_id":52009686171953,"sku":null,"price":1079.0,"currency_code":"AUD","in_stock":true},{"title":"Neural Zoomer Plus AND ApoE Add-On","offer_id":52009686204721,"sku":null,"price":1129.0,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0951\/1338\/0145\/files\/neural.jpg?v=1762308659","url":"https:\/\/shop.healthhunter.au\/products\/vibrant-america-neural-zoomer-plus-test","provider":"Health Hunter","version":"1.0","type":"link"}