{"product_id":"rn-labs-nac-powder","title":"RN Labs NAC Powder 100g","description":"\u003cp\u003e\u003cstrong\u003eRN Labs' NAC oral powder 100g\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eN-Acetyl-Cysteine (NAC) is a sulphur-bearing amino acid key to numerous metabolic processes, including the synthesis of Glutathione, antioxidant and detoxification functions, as well as the regulation of various neurological and inflammation\/immune mechanisms.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHighest purity\u003c\/li\u003e\n\u003cli\u003eImproved palatability\u003c\/li\u003e\n\u003cli\u003eConsciously sourced\u003c\/li\u003e\n\u003cli\u003eVegan friendly - Non animal origin\u003c\/li\u003e\n\u003cli\u003eSupports glutathione synthesis \u0026amp; detoxification\u003c\/li\u003e\n\u003cli\u003ePowerful mucolytic agent\u003c\/li\u003e\n\u003cli\u003eScavenger of free radicals\u003c\/li\u003e\n\u003cli\u003eSupports antiviral defenses\u003c\/li\u003e\n\u003cli\u003eFree from gluten, dairy, egg, yeast, soy, sugar and additives\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePer tub: 100g oral powder\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSuggested use\u003c\/strong\u003e\u003cbr\u003eAdults: Common Dosage Range: 700mg – 2800 mg per day (It is advisable to begin supplementation at the low end of the dose range, increasing if required).\u003c\/p\u003e\n\u003cp\u003eEach bottle is clearly labelled with ingredient density, to facilitate ease of dosage calculations, and a scoop is provided with each bottle to assist with accurately determining patient doses.\u003c\/p\u003e\n\u003cp\u003eCan be taken with or without food.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline; color: #000000;\" data-mce-style=\"text-decoration: underline; color: #000000;\"\u003e\u003cstrong\u003eProduct Education:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline; color: #000000;\" data-mce-style=\"text-decoration: underline; color: #000000;\"\u003eIngredients: Pure Pharmaceutical-Grade N-Acetylcysteine (NAC).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003cbr\u003eIf pregnant, consult your healthcare practitioner before using this product.\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003cp\u003eNAC is safe and well tolerated when administered orally, with mild gastrointestinal symptoms being reported at doses \u0026gt;3g per day.\u003c\/p\u003e\n\u003cp\u003eAvoid use in those with active peptic ulcers. Appropriate dosing may be resumed when sufficient ulcer healing has been achieved.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline; color: #000000;\" data-mce-style=\"text-decoration: underline; color: #000000;\"\u003eOnce supplements leave our store they cannot be returned or refunded. Please choose carefully.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003eGlycine and NAC is an interesting combination:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eSupplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks (\u003ca title=\"NAC and Glycine study\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35975308\/\" target=\"_blank\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35975308\/\"\u003eSTUDY LINK\u003c\/a\u003e)\u003c\/p\u003e\n\u003cp\u003eGlycine and N-Acetylcysteine Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage (\u003ca title=\"NAC and glycine improves Mitochondrial Dysfunction\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8912885\/#:~:text=PMID%3A%2035268089-,GlyNAC%20(Glycine%20and%20N%2DAcetylcysteine)%20Supplementation%20in%20Mice%20Increases,Nutrient%20Sensing%2C%20and%20Genomic%20Damage\" target=\"_blank\" data-mce-href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8912885\/#:~:text=PMID%3A%2035268089-,GlyNAC%20(Glycine%20and%20N%2DAcetylcysteine)%20Supplementation%20in%20Mice%20Increases,Nutrient%20Sensing%2C%20and%20Genomic%20Damage\"\u003eSTUDY LINK\u003c\/a\u003e)\u003c\/p\u003e\n\u003cp\u003eA Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage (\u003ca title=\"NAC and glycine helps increase glutathione levels in older adults\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2022.852569\/full\" target=\"_blank\" data-mce-href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2022.852569\/full\"\u003eSTUDY LINK\u003c\/a\u003e)\u003c\/p\u003e\n\u003cp\u003e \u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eGlutathione is one of the main endogenous antioxidants. Found in virtually every cell of the body's glutathione defends against free radicals, in part by recycling other antioxidants. It also supports detoxification and other critical aspects of cell function.1 Increased glutathione levels have been linked to supporting a reduction in oxidative stress and DNA damage.2 Cysteine and glycine are necessary precursors for glutathione (GSH) synthesis, but the required amounts may not be met by dietary intake alone, particularly as we age.3 Co-supplementation of these nutrients has been shown to promote intracellular glutathione levels.4,5 In a small study involving older individuals, two weeks of supplementation with a combination of N-acety-l-cysteine (NAC) and glycine raised red blood cell (RBC) glutathione levels more effectively than either amino acid alone.5 In one study, supplementation with the combination of NAC and glycine resulted in 32% higher RBC glycine, 46% higher RBC cysteine and a 53% increase in RBC GSH concentration. There was also a significant improvement in the ratio of reduced (active) GSH to oxidized glutathione (GSSG). Increased GSH was associated with improvement in antioxidant status as measured by F2-isoprostanes, as well as mitochondrial fatty acid oxidation.6 In another study comparing young and older subjects, elderly subjects had 55% lower RBC glycine, 24% lower RBC cysteine, and 46% lower RBC glutathione at baseline, as well as lower reduced (active) GSH to GSSG ratios. Supplementation with NAC and glycine in elderly subjects resulted in RBC levels of glycine, cysteine, and glutathione, as well as GSH:GSSG ratio, comparable to young unsupplemented subjects.4 NAC and glycine have been shown to maintain healthy cytokine release during times of metabolic stress.7 Research suggests that glycine may moderate TNFα and promote IL-10 to support cytokine balance, and that glycine intake is positively associated with cardiometabolic health.8 Studies indicate that supplementation with NAC also supports mood and social functioning.9 It is believed that cysteine influences the reward-reinforcement pathway by modulating the glutamate system.10 NAC additionally promotes immune defenses and supports the health of epithelial cells and cilia in the respiratory tract.11 The affinity of NAC for lung tissue, together with its natural sulfur content, allows it to disrupt disulfide bonds within mucus, thinning and easing its expulsion.12 In a randomized, double-blind trial involving mostly older individuals, 600 mg of NAC twice daily showed significant support for respiratory and immune function.13\u003c\/p\u003e\n\u003ch4\u003eReferences\u003c\/h4\u003e\n\u003col\u003e\n\u003cli\u003eRichie JP Jr, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEur J Nutr\u003c\/em\u003e. 2015 Mar;54(2):251-63.\u003c\/li\u003e\n\u003cli\u003eZhang Q, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMedicine (Baltimore).\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e2018 Nov;97(45)\u003c\/li\u003e\n\u003cli\u003eSekhar RV, et al.\u003cem\u003eAm J Clin Nutr\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e2011 Sep;94(3):847-53\u003c\/li\u003e\n\u003cli\u003eRoes EM, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eClin Chem Lab Med\u003c\/em\u003e. 2002 May;40(5):496-8.\u003c\/li\u003e\n\u003cli\u003eGuthikonda, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAmerican Geriatrics Society\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003eAnnual Scientific Meeting,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e, 2006.\u003c\/li\u003e\n\u003cli\u003eNguyen D, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Clin Endocrinol Metab\u003c\/em\u003e. 2014 Jan;99(1):169-77.\u003c\/li\u003e\n\u003cli\u003eCruz M, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e. J Endocrinol Invest\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e2008 Aug;31(8):694-9.\u003c\/li\u003e\n\u003cli\u003eDing, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCirc Cardiovasc Genet\u003c\/em\u003e. 2016 Dec;9(6):541-547.\u003c\/li\u003e\n\u003cli\u003eBerk M, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBiol Psychiatry\u003c\/em\u003e. 2008 Sep 15;64(6):468-75.\u003c\/li\u003e\n\u003cli\u003eGrant JE, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eArch Gen Psychiatry\u003c\/em\u003e. 2009 Jul;66(7):756-63\u003c\/li\u003e\n\u003cli\u003eOzdemir ZC, et al.\u003cem\u003eHemoglobin.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e. 2014;38(5):359-64.\u003c\/li\u003e\n\u003cli\u003eTse HN, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eChest.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e2013 Jul;144(1):106-18\u003c\/li\u003e\n\u003cli\u003eDe Flora S, et al.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEur Respir J\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eJ. 1997 Jul;10(7):1535-41.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cul\u003e\u003c\/ul\u003e","brand":"RN LABS","offers":[{"title":"Default Title","offer_id":52009687646513,"sku":"PC1933.100","price":28.95,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0951\/1338\/0145\/files\/NAC-Powder.jpg?v=1762308705","url":"https:\/\/shop.healthhunter.au\/products\/rn-labs-nac-powder","provider":"Health Hunter","version":"1.0","type":"link"}